Sarah Clarke, a native of St. Louis, began acting in the theater while working as an architectural photographer. She moved to New York to study at Circle in the Square and to work with, among others, The Willow Cabin Theater Company, Axis Theater Company and Robert Wilson.
In her first short film, Pas de Deux, she won a CiNY Award for Outstanding Performance at the Brooklyn Film Festival.
Since then, she has made guest appearances on Sex in the City, Ed and House, M.D., and has appeared in two independent films, The Accident and Emmett's Mark.
Her more recent film appearances include Thirteen and Happy Endings.